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Author

Xuerui Yang

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Open access Sep 2026

Interpretable machine learning enables de novo mapping of cell type-specific RNA splicing regulation from scRNA-seq data

CASREL is developed, a machine learning framework that infers candidate regulatory circuitry between RNA-binding proteins and alternative splicing from single-cell data, enabling de novo mapping of putative cell-specific regulatory networks.

Xian-Ke Xiang, Xue-Rui Yang · 0 citations
Open access Jul 2026

NOD1/2 signaling in macrophages drives adaptive immune resistance in cancer

NOD1/2 is defined as a novel innate immune checkpoint that orchestrates therapy-induced adaptive resistance and highlight this pathway as a promising target to overcome treatment resistance in refractory cancers.

Xi-Duan Wei, Li Yang, Yuting Wang et al. · 0 citations

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