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Author

Xue-Shi Huang

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Review Open access Sep 2026

Dietary flavonoids target the gut-liver axis for the management of cholestatic liver injury.

Cholestatic liver injury (CLI) is a progressive liver disorder characterized by impaired bile acid (BA) synthesis, transport, and excretion. This dysfunction leads to the intrahepatic accumulation of toxic BAs, which in turn triggers hepatic oxidative stress, inflammation, and subsequent fibrogenesis. Through enterohep...

Dong-Song Bai, Shao-Qiang Fan, Yu Mu et al. · 0 citations
Sep 2026

A synergistic antifungal agent from Ligusticum chuanxiong: Total synthesis, biological evaluation, and mechanism of ligustrumdiol A.

Invasive fungal infections threaten immunocompromised patients, and the toxicity, resistance, and narrow spectrum of current therapies demand new agents. A chemical investigation of the medicinal plant Ligusticum chuanxiong led to the isolation of a rare pentyl-substituted cyclohexene derivative, ligustrumdiol A (LDA)....

Jun-Wei Yang, Jun-Feng Tan, Yifan Hu et al. · 0 citations

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