Author

Xue Wang

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Open access Sep 2026

Fibronectin mediates APOE4-driven blood–brain barrier dysfunction in Alzheimer’s disease

Blood–brain barrier (BBB) dysfunction is an early feature of Alzheimer’s disease (AD) and is particularly pronounced in individuals carrying the APOE ε4 allele, but the mechanisms linking APOE ε4 to BBB failure remain unclear. Here we show that astrocyte-derived fibronectin (FN1) is a key mediator of apolipoprotein E4...

P. Bhattarai, E. Yılmaz, Elif Öykü Cakir et al. · Nature Aging · 1 citation

Open access Sep 2026

ASOFormer: a Transformer-based model for predicting antisense oligonucleotide efficacy to support therapeutic candidate prioritization

A novel Transformer-based neural network that predicts the inhibition efficiency of RNase H-mediated ASOs from sequence, predicted secondary structure, and chemical modification features, ASOFormer achieved the best overall accuracy and prioritized the strongest inhibitors.

N. Dove, Yu-Hao Min, Özkan Iş et al. · bioRxiv · 0 citations

Open access Aug 2026

Brain multiomic profiling identifies tau-related transcriptomic dysregulation in Alzheimer’s disease

A hypothetical model of dynamic brain gene expression changes that track with progressive Alzheimer’s disease proteostasis is proposed and found that a beneficial brain biochemical state of higher total tau and lower phospho-Tau is associated with increased levels of synaptic, DNA damage/repair, nucleic acid metabolism...

Stephanie R. Oatman, Zachary S. Quicksall, Xue Wang et al. · Brain Communications · 0 citations