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Open access Sep 2026

Multilevel synergistic anticancer mechanisms of Punica granatum L. peel polyphenols targeting the pan-cancer proliferation target PCNA: a combined analysis based on network pharmacology, molecular dynamics simulation, and UPLC-Q-TOF-HRMS

Punica granatum L. peel is rich in tannins and flavonoids. Modern pharmacological studies have indicated its multi-target anticancer potential; however, the molecular recognition mechanisms between its active components and key targets remain to be systematically clarified. In this study, network pharmacology, com...

Shi-Jia Lu, Meng-Jia Yan, H. Du et al. · 0 citations

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