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Review Open access Sep 2026

Beyond the tumor microenvironment: a hierarchical immune-circuit model of immune checkpoint blockade resistance

Immune checkpoint blockade (ICB) produces durable tumor control in a subset of patients, yet resistance is usually interpreted through tumor-intrinsic lesions or suppression within the tumor microenvironment (TME). We propose that ICB resistance can also be organized as failure of a multiscale antitumor immune circuit...

Xue Zhao, Han Wang, Ya-Nan Liu et al. · 0 citations
Open access Aug 2026

Intelligent diagnosis of vocal cord lesions via multimodal deep learning: integrating laryngoscopy, voice, and biomarkers

Accurate pre‑operative diagnosis of vocal cord lesions remains challenging. We developed a multimodal deep learning model that integrates laryngoscopic images, voice recordings, and biochemical markers to improve diagnostic accuracy. In this retrospective study (2020–2025), a total of 425 patients were enr...

Xue Zhao, Shuang Li, Linlin Zheng et al. · 0 citations

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