Author

Xue-Zhi Zhou

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Open access Aug 2026

Construction and exploratory validation of a digital pathology prognostic model for stage II–III colorectal cancer based on contrastive learning and attention mechanisms

Introduction Although TNM staging is the standard framework for prognostic assessment in colorectal cancer (CRC), patients within the same stage can have heterogeneous outcomes. This study aimed to extract tumor-tissue features from whole-slide images (WSIs), develop an image-derived prognostic model for stage II–III C...

Yi-Zhan Lu, Zhi-Feng Qu, Chong-Bao Sun et al. · Frontiers in Oncology · 0 citations

Aug 2026

Large-scale EEG neural network changes following accelerated high-definition transcranial direct current stimulation in major depressive disorder: A randomized controlled trial.

BACKGROUND High-density transcranial direct current stimulation (HD-tDCS) shows efficacy in major depressive disorder (MDD), but underlying mechanisms remain unclear. Electroencephalogram (EEG) microstates reflect large-scale network dynamics, and MDD patients exhibit microstate abnormalities. Whether HD-tDCS modulates...

Zongya Zhao, Ming-Jie Zhu, Hai-Yue Dai et al. · Progress in Neuro-psychophar... · 0 citations

Open access Jul 2026

An enzyme-specific protein language model for catalytic property prediction

This manuscript introduces EnzGFM, an enzyme-specific hybrid model that improves both accuracy and efficiency across multiple prediction tasks and, together with the EnzGFM-Agent pipeline, demonstrates the ability to identify experimentally validated beneficial variants while reducing screening effort.

Chong Wang, Mengyao Li, Shaolei Geng et al. · Nature Communications · 0 citations