Cell-Intrinsic MHC-I Expression Sustains NK Cell Effector Function and Its Loss Drives Exhaustion in Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC), characterized by lack of targetable receptors and an immunosuppressive tumor microenvironment (TME), remains one of the most aggressive breast cancer subtypes with poor prognosis despite emerging immunotherapies. While adaptive immunity has been extensively studied, the role of inn...