Xukai Jiang

Collaborative multi-agent intelligence uncovers subtype-selective allosteric sites at GPCR-lipid interaction interface

A five-agent workflow to systematically identify divergent protein-membrane-interface sites across class A GPCRs and exploit them for selective allosteric ligand discovery is developed, establishing a scalable strategy for translating GPCR membrane-interface divergence into precise allosteric sites and testable subtype-selective ligand candidates.