Open access
Aug 2026
N6-methyladenosine epitranscriptomic remodeling drives infantile aortic coarctation via FTO-mediated repression of PTEN and GRK5
It is found that global m6A levels are significantly elevated in CoA tissues, with widespread hypermethylation events enriched in focal adhesion and extracellular matrix remodeling pathways, providing novel epigenetic targets for therapeutic intervention.
Wen-Lei Li, Wei-Dan Chen, Minghui Zou et al.
· Frontiers in Cardiovascular... · 0 citations