Author

Xuping Xie

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Aug 2026

Siglec-15 and PD-1 checkpoint blockade in combination with oncolytic Zika virus infection confers protection against immune-resistant gliomas.

BACKGROUND : The glioblastoma (GBM) immunosuppressive tumor microenvironment is a clinical challenge. Oncolytic Zika virus (ZIKV) has emerged as a promising therapy, targeting treatment-resistant glioma stem cells, stimulating CD8+ T-cell-mediated immunity and extends survival in preclinical models but myeloid cell-dri...

Ashwani Kesarwani, Amber Neil Griffith, Sonam Verma et al. · Neuro-Oncology · 0 citations

Open access Aug 2026

HIF1A-dependent induction of alveolar miR-147b dampens SARS-CoV-2-associated ARDS via direct targeting of viral RNA.

Alveolar epithelial cell-derived miR-147b serves as an endogenous lung protective miRNA against SARS-CoV-2-associated ARDS by directly targeting virus-encoded RNA, revealing a previously unrecognized antiviral and lung-protective mechanism.

Xiao-Yi Yuan, Jieun Kim, K. Figarella et al. · Anesthesiology · 0 citations