USP53-ALKBH5 axis inhibition boosts m6A-modified TERT RNA degradation: A potential therapeutic strategy for glioblastoma.
Glioblastoma (GBM) is the most common malignant glioma, with a high recurrence rate and a poor prognosis. Deubiquitinating enzyme ubiquitin-specific peptidase 53 (USP53), known to enhance the stability of downstream proteins, exhibits distinct functions in different tumors. The function of USP53 in GBM progression rema...