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Author

Y. Chan

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2 papers indexed here

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Oct 2026

Berberine increases the sensitivity of sorafenib in human hepatocellular carcinoma via inducing HIF-1α-mediated energy crisis.

Findings provide functional evidence that BBR sensitizes HCC to SORA by inducing an HIF-1α/PFKP/LDHA-mediated energy crisis, highlighting the preclinical potential of BBR as a candidate adjuvant agent for overcoming SORA resistance in HCC.

Wei Guo, Zi-Xin Feng, Ming-Hsien Hu et al. · 0 citations
Review Open access Aug 2026

The Role and Mechanistic Effects of Gut Microbiota Metabolites in Immunotherapy for Hepatocellular Carcinoma

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced hepatocellular carcinoma (HCC), but low response rates and drug resistance remain major clinical challenges. Recent data underscore the gut-liver axis as a major determinant of therapeutic outcomes, particularly amid an epidemiological tr...

Y. Chan, Pengde Lu, Jiaqi Zou et al. · 0 citations

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