Author

Y. Chern

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Open access Oct 2026

Oxidative stress-induced microglial CD22 upregulation impairs phagocytosis and exacerbates Huntington’s disease

Huntington’s disease (HD) is a neurodegenerative disorder caused by an abnormal polyglutamine expansion in mutant huntingtin (mHTT) and is characterized by movement dysfunction and neuronal loss. Siglecs, a family of sialic acid-binding proteins, are expressed on brain microglia and implicated in Alzheimer’s dise...

Yan-Hua Lee, Jian-Jing Siew, Chia-Wei Lee et al. · Molecular Neurodegeneration · 0 citations

Open access Sep 2026

ENT1 inhibition links oligodendrocyte lipid metabolism to connectivity in tauopathy

Metabolic dysfunction, altered adenosine signaling, and white matter abnormalities are implicated in tauopathies, but their relationship to network disconnection remains unclear. Myelinating oligodendrocytes may represent a metabolically vulnerable hub linking these processes to circuit dysfunction.

Ching-Pang Chang, Ching-Wen Chang, Ching-Wen Wu et al. · Alzheimer's & Dementia · 0 citations