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Hck signaling drives long-distance ECM degradation through endo-exocytosis coupling in macrophages
The diversity of strategies implicated in extracellular matrix (ECM) degradation supporting cell invasion has been poorly achieved. Unlike invasive breast cancer cells, which predominantly degrade the ECM locally via an invadosome-associated degradation, dynamic quantification of live imaging of degradation of physiolo...
Divergent SAGA complexes shape the Toxoplasma transcriptome for lytic cycle progression and host interaction
Histone acetylation governs Toxoplasma gondii gene expression, developmental plasticity and virulence, yet the organization and deployment of its acetyltransferase machinery remain poorly understood. Here, we show that T. gondii rewired this process using a plant-like system built around the acetyltransferase TgGCN5b,...