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Y.-D. Zhang

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Open access Sep 2026

137. Succinate induces compulsive-like behavior via medial prefrontal cortex glutamatergic neuron excitation-inhibition imbalance in male mice

Abstract Background Obsessive-compulsive disorder (OCD), a disabling psychiatric disorder characterized by obsessions (commonly anxiety-associated) or compulsions, remains mechanistically elusive, which hinders therapeutic development. Our previous study revealed elevated succinic acid levels in both the serum of OCD p...

Y. Li, Y.-D. Zhang, X.-Y. Wu et al. · 0 citations

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