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Author

Y. Dong

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Open access Oct 2026

Common centromeric variation associates with molecular and complex traits in humans

Human centromeres harbor extensive structural variation that has remained largely inaccessible to human genetics because their repetitive -satellite arrays are absent from standard reference and imputation panels. Here we catalog 188,589 centromeric structural variants (SVs) from haplotype-resolved long-read assemblies...

Y. Dong, D. Cutler, J. Weinstock · 0 citations
Open access Oct 2026

Rare variant burden complements polygenic risk in breast cancer and is associated with earlier diagnosis

Breast cancer affects approximately one in eight US women during their lifetime, and about 10% of new cases occur before age 45. Polygenic risk scores (PRS) are associated with breast cancer risk, and previous studies have evaluated PRS alongside pathogenic-variant carrier status. Whether a continuous, gene-effect-weig...

Z. Yu, Y. Dong · 0 citations

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