The dynamic regulation of m6A RNA methylation in the brain is summarized, its neurobiological functions are discussed, its potential role in stress-related pathology and MDD is critically evaluated, and m6A modification may represent a plausible epitranscriptomic mechanism governing synaptic plasticity in the depressed...
Anuj K. Verma, Hiroaki Mori, B. Roy et al.· Frontiers in Molecular Neuro...· 0 citations
It is suggested that the interaction between epigenetic and epitranscriptomic mechanisms is a key factor in determining risk and resilience for neuropsychiatric disorders, and offers new directions for future research and therapy development.
Y. Dwivedi, B. Roy· Brain : a journal of neurolo...· 0 citations
IRF1 mRNA expression was increased in the hippocampus of both MDD subjects and CSDS mice, supporting a potential miR-20a-5p-IRF1 regulatory axis involved in inflammatory signaling in MDD.
Mariko Okano, Y. Yoshino, Anuj K. Verma et al.· Psychiatry and Clinical Neur...· 0 citations
These findings provide a comprehensive single-nucleus atlas of gene regulation in the MDD PFC, highlighting coordinated dysfunction across neurons, glia, and vascular cells.
A. Francis, Y. Dwivedi· International Journal of Neu...· 0 citations
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