Author

Y. Funakoshi

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Open access Sep 2026

Triplet chemotherapy with Gemcitabine, Nab-paclitaxel, and S-1 achieves high response and conversion rates in advanced pancreatic cancer: A multicenter phase II study (GeNeS1S trial).

BACKGROUND S-1 has demonstrated non-inferiority to gemcitabine (GEM) in overall survival (OS) in advanced pancreatic cancer and superiority in the adjuvant setting for resectable disease. This study evaluated the efficacy and safety of S-1 combined with GEM plus nab-paclitaxel (nPTX) in advanced pancreatic cancer. ME...

Yoshiaki Nagatani, N. Chayahara, Hironaga Satake et al. · European Journal of Cancer · 0 citations

Open access Sep 2026

First-week expansion of activated peripheral B-cell subsets is associated with grade 3 or higher immune-related adverse events after nivolumab plus ipilimumab

First-week expansion of activated peripheral B-cell subsets after nivolumab plus ipilimumab was associated with subsequent severe irAEs, which support future studies of early B-cell monitoring within integrated multimarker assessments of irAE risk.

H. Takakura, Y. Funakoshi, T. Koyama et al. · medRxiv · 0 citations

Open access Apr 2026

LM-QASAS: reference-free identification of antigen-specific sequences from the BCR repertoire using antibody language models

LM-QASAS provides a rapid, high-precision platform for monitoring humoral immunity against emerging threats by mapping sequences into a high-dimensional semantic embedding space, and identifies functionally convergent clusters of sequences that are semantically similar and exhibit transient expansion upon immune stimul...

Genki Masuda, Y. Funakoshi, S. Iizumi et al. · medRxiv · 0 citations