Author

Y. Huang

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Open access Sep 2026

Human genetic risk for major depressive disorder implicates motor cortex PVALBâº inhibitory neurons

Major depressive disorder (MDD) is highly polygenic, but the cellular and anatomical contexts through which inherited risk contributes to disease biology remain incompletely understood. Here we integrated large-scale MDD genome-wide association studies with an adult human brain single-cell discovery atlas and five inde...

Y. Ma, H. Han, C. Chen et al. · medRxiv · 0 citations

Open access Aug 2026

Genetic architecture and biological relevance of intrinsic white matter functional activity

White matter (WM) BOLD signals, long dismissed as non-neuronal noise, are increasingly recognized as intrinsic, anatomically organized functional activity. However, the genetic architecture of intrinsic WM functional activity remains poorly understood. Here, we performed genome-wide and phenome-wide analyses of WM frac...

Y. Huang, A. Toga, L. Zhao · medRxiv · 0 citations

Y. Huang

Human genetic risk for major depressive disorder implicates motor cortex PVALBâº inhibitory neurons

Genetic architecture and biological relevance of intrinsic white matter functional activity

Human genetic risk for major depressive disorder implicates motor cortex PVALBâº inhibitory neurons