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The decay of the Lef1 - Srsf3 -miRNA axis as a core molecular alteration underlying SC aging is defined and revealed that local SC aging may contribute to organismal aging.
This focused narrative review reappraises biologic therapies in SSc using a manifestation-based framework spanning cutaneous, pulmonary, vascular, gastrointestinal, musculoskeletal, and global or composite outcomes and argues that vasculopathy may represent an upstream pathogenic layer that constrains the disease-modif...
This dataset provides a resource for investigating transcriptional dynamics downstream of Sbno1 and Trp53 in embryonic cortical development, and for applying diverse computational and integrative analytical approaches.
It is shown that dietary RJ enhances stem/progenitor cell activity with age- and tissue-dependent Chi3l1 -mediated increases in CD206-positive macrophages, suggesting that Chi3l1 is a physiologically regulated immune mediator, rather than a pathogenic factor in disease contexts, highlighting the importance of mechanis...
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