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Author

Y. Mineharu

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Open access Aug 2026

Plasma signatures of type 2 inflammation and vascular remodeling in moyamoya disease.

BACKGROUND Moyamoya disease (MMD) is an idiopathic cerebrovascular disorder in which chronic inflammation has been implicated, along with genetic susceptibility, including the RNF213 variants. In this study, we examined the relationship between type 2 inflammation and MMD. METHODS Blood samples were collected from th...

Silsu Park, Y. Mineharu, Takeshi Funaki et al. · 0 citations
Sep 2026

RNF213 regulates palmitate signaling through AAA+ and RZ-finger domains, a process enhanced by gain-of-function moyamoya disease-associated mutations.

RNF213 was originally identified as a susceptibility gene for Moyamoya disease (MMD), and its variants are also associated with other vascular occlusive disorders, including pulmonary arterial hypertension and large-artery atherosclerosis. RNF213 encodes a large protein with AAA+ ATPase and E3 ubiquitin ligase activiti...

Qianying Huang, Tohru Tezuka, Kei Iida et al. · 0 citations

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