Ribosome heterogeneity can regulate translation, but how changes in ribosome chemistry reshape cellular programs and contribute to diseases such as cancer remains incompletely understood. Here we show that SNORA81-guided pseudouridylation at a single 28S ribosomal RNA site, U4636, links ribosome heterogeneity to select...
Laurence Faucher-Giguère, Andrea Rivera-Pizana, Baudouin Seguineau de Préval et al.· bioRxiv· 0 citations
Dynamic ribosome heterogeneity has emerged as a potential layer of translational regulation, but whether variation in ribosomal RNA (rRNA) modification stoichiometry can selectively control the translation of mRNAs with shared encoded features remains unclear. Here we show that SNORA81-guided pseudouridylation at U4636...
Laurence Faucher-Giguère, Andrea Rivera-Pizana, Baudouin Seguineau de Préval et al.· bioRxiv· 0 citations
Nucleic acid damage under oxidative stress conditions is a well-established phenomenon relevant to evolution of all living organisms. While well investigated for DNA, cellular RNAs are also a subject of extensive damage, featuring similar reactivity towards reactive oxygen species generated by external factors and cell...
Kasturi Raorane, Marlies Weber, V. Marchand et al.· RSC Chemical Biology· 0 citations
It is demonstrated that expression of SNHG1, SNHG12, and SNHG30 in EWS cells contributes to the maintenance of cancer cell fitness via their role in intron-processed snoRNAs encoded in SNHG1 and SNHG12.
Marcela Briones-Martin-Del-Campo, Alex G. Lee, Truc Dinh et al.· NAR Cancer· 0 citations
Findings support a role for snoRNA-guided rRNA modification as a novel non-genomic mechanism in early adaptive responses to crizotinib therapy in LUAD.
Nour-El-Houda Mourksi, Caroline Isaac, J. Ripoll et al.· Cell Death & Disease· 0 citations
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