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Author

Y. Pommier

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Open access Aug 2026

Genome-wide mapping reveals increased R-loops in topoisomerase III-beta-deficient human cells

Summary Aberrant R-loops can cause genomic DNA damage. We mapped R-loops across the genomes of human colon carcinoma HCT116 and fibrosarcoma HT1080 cells deficient for topoisomerase III-beta (TOP3B) by performing DNA-RNA immunoprecipitation followed by high-throughput sequencing (DRIP-seq). Knocking out TOP3B globally...

Sourav Saha, A. Dhall, Shar-yin N. Huang et al. · 0 citations
Open access Jul 2026

TOP1MT rs2293925 is an enhancer-active regulatory SNP that shapes mitochondrial R-loop dynamics.

Data support a dual-effect model in which rs2293925 increases TOP1MT expression and is associated with altered mitochondrial R-loop dynamics, linking common genetic variation to mitochondrial nucleic acid stress in disease-relevant contexts.

Dóra Varga, Zsolt Ráduly, Beáta Boros-Oláh et al. · 0 citations

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