Recombinant Production, Biochemical Characterization, and In Vitro Evaluation of an EWS-FLI1-Derived Peptide for Ewing Sarcoma.
Ewing sarcoma is an aggressive malignancy characterized by the EWS-FLI1 fusion oncoprotein, which remains challenging to target because of its intrinsically disordered nature and lack of intrinsic enzymatic activity. EWSPEP, a peptide derived from the EWS-FLI1 fusion junction region, has previously been investigated in...