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Review Open access Sep 2026

Focal Cortical Dysplasia Type II: Somatic Mutations, Molecular Mechanisms, and Integrative Multi‐Omics Framework

ABSTRACT Background Focal cortical dysplasia Type II (FCD II) is a major cause of drug‐resistant epilepsy in children. Somatic mosaic variants affecting the PI3K–AKT–mTOR pathway are implicated in a substantial proportion of cases. The links between genotype, cellular pathology, epileptogenic networks, and clinical out...

Ze-Sheng Li, Yi-He Wang, Jian-Wei Shi et al. · 0 citations

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