The Nrf2/HIF-1α/BNIP3 Axis Mediates Mitophagy and Hyperproliferative Behavior in Hypertrophic Scar Fibroblasts.
BACKGROUND Hypertrophic scarring is driven in part by persistent fibroblast activation, but the mechanisms linking hypoxia, mitochondrial dysfunction, and fibrotic behavior remain incompletely defined. In our previous work, abnormal mitophagy and elevated BNIP3 expression were observed in hypertrophic scar fibroblasts....