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Y. Shen

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2026

Effect of Structure-Guided Single Mutant on Nicotinamide Coenzyme Specificity of Glucose Dehydrogenase from Bacillus Megaterium

A structure-guided rational design to invert the coenzyme specificity of GDH by targeting a single residue within the conserved GXXXGXG motif of the Rossmann fold provides a generalizable framework for engineering cofactor preference in short-chain dehydrogenase/reductase family enzymes.

Y. Shen, Ke-Ju Jing · 0 citations

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