Delirium is an acute neurocognitive impairment triggered by physiological stressors such as medical illness, surgery, or medication use. Although often transient, it is associated with adverse clinical outcomes. Current management primarily relies on nonpharmacological or symptomatic approaches; however, their effectiv...
Kyoka Nakatomi, Koki Okawa, Y. Shigetsura et al.· Biological and Pharmaceutica...· 0 citations
Abstract Background Post-stroke delirium occurs in approximately 24–43% of patients and is associated with reduced adherence to acute treatment and rehabilitation, ultimately worsening functional outcomes. Preventive management has received increasing attention, and several studies in intensive care settings have demon...
Y. Shigetsura, Y. Miyoshi, D. Hira et al.· International Journal of Neu...· 0 citations
This study provides the first evidence that hippocampal Tenm4 deficiency induces depression-like behavior phenotypes through impaired oligodendrocyte differentiation and promoting demyelination.
Yuichiro Sugimori, Y. Yano, Takashi Asano et al.· Neuropharmacology· 0 citations
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