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Open access Oct 2026

Distinct NGS mutational landscape and prognostic implications in early-onset colorectal cancer: A dual-cohort analysis of TCGA PanCancer Atlas and MSK-IMPACT 50K

Background Early-onset colorectal cancer (EOCRC), defined as CRC diagnosed before age 50, is rising globally. The genomic landscape of EOCRC has been characterized in several prior studies, but the reproducibility of findings across independent cohorts, the impact of adjustment for tumor stage and sample type, and the...

Elif Sertesen Çamöz, Osman Bilge Kaya, Hakan Erçelebi et al. · 0 citations
Review Open access Jul 2026

Role of Ovarian Development Genes in the Pathogenesis of Polycystic Ovary Syndrome

Objective:    Polycystic ovary syndrome (PCOS) represents the primary endocrine dysfunction among women of reproductive age, characterized by marked phenotypic diversity across reproductive, metabolic, and neuroendocrine domains. Despite extensive clinical characterization, its precise etiology remains unresolved, invo...

Ayşegül Karahanoğlu, Mehmet Ozer, Y. Terzi et al. · 0 citations

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