In congenital heart disease-associated pulmonary arterial hypertension (CHD-PAH), right heart catheterisation is essential, but conventional haemodynamic indices from the ESC simplified four-strata model have limited prognostic value. Whether composite indices—PVRI, effective arterial elastance (Ea), pulmonary ar...
Q. Yu, Y. Wu, J. He· European Heart Journal· 0 citations
Background Vericiguat, a novel soluble guanylate cyclase (sGC) stimulator, is indicated for high-risk worsening heart failure (HF). However, its real-world reporting profile when added to contemporary quadruple guideline-directed medical therapy (GDMT)—effectively creating a “quintuple” regimen—remains largely unexplor...
Da-Qiu Chen, Y. Wu, Zi-Xun Wang et al.· Frontiers in Cardiovascular...· 0 citations
Mitochondrial dysfunction is a pivotal driver of vascular endothelial injury and atherogenesis. This study aimed to evaluate the therapeutic potential of geranylgeranylacetone (GGA), a clinically established gastroprotective agent, in atherosclerosis and to explore the underlying molecular mechanisms. Apolipoprotein E-...
Meng Li, Yi Chen, Zhi-Jian Wu et al.· Biochemical Pharmacology· 0 citations
Stepwise DAPT de-escalation may be a safe and effective strategy for ACS patients with bifurcation lesions undergoing DCB-only angioplasty and Bleeding Academic Research Consortium type 3 or 5 bleeding.
Yong-Meng Yan, Qiong Wang, Yi Liu et al.· International Journal of Car...· 0 citations
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