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Y. Yamanishi

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Open access Sep 2026

Auxin-Activated Caspase 9 System (AuxiCasp9), a Suicide Switch for Engineered Cells

Engineered cells incorporating synthetic gene circuits have been developed for therapeutic and diagnostic applications. However, cell proliferation and long-term engraftment may pose a risk of unpredictable toxicities. To address this issue, a suicide switch that can be selectively activated by exogenous stimuli has...

Satoshi Yoshimoto, Shigeo S. Sugano, S. Sakuma et al. · 0 citations

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