Open access
Sep 2026
Gastroesophageal reflux disease (GERD) exhibits substantial comorbidity with psychiatric disorders, yet the biological basis underlying this relationship remains unclear. Here, we integrated large-scale GWAS meta-analysis, Mendelian randomization, Genomic Structural Equation Modeling, local genetic correlation analysis...
X. Wang, Q. Zhang, Q. Wu et al.
· medRxiv · 0 citations
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Open access
Sep 2026
Major depressive disorder (MDD) is highly polygenic, but the cellular and anatomical contexts through which inherited risk contributes to disease biology remain incompletely understood. Here we integrated large-scale MDD genome-wide association studies with an adult human brain single-cell discovery atlas and five inde...
Y. Ma, H. Han, C. Chen et al.
· medRxiv · 0 citations
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Open access
Aug 2026
Migraine is a leading cause of disability, yet preventive treatment remains largely empirical despite the availability of several mechanistically distinct therapies. Genetic data can clarify mechanisms and therapeutic hypotheses when association signals are integrated with molecular and clinical data. We meta-analyzed...
C. Overstreet, M. Galimberti, K. Harsan et al.
· medRxiv · 0 citations
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