552. Can locus coeruleus structural and functional changes serve as a biomarker for Alzheimer's disease: a systematic review and meta-analysis
Abstract Background The locus coeruleus (LC), the brain’s principal noradrenergic nucleus, is implicated early in Alzheimer’s disease (AD) pathophysiology. Growing evidence from animal models, human post-mortem studies, and in vivo neuroimaging suggests that LC structural and functional alterations may reflect AD-relat...