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Open access Sep 2026

Macrophage-derived CD38 mediates colitis through NAD+ depletion.

Colitis, a chronic inflammatory bowel disease (IBD), is pathologically linked to immune dysregulation; however, the contribution of cellular metabolic alterations to its pathogenesis remains incompletely understood. In this study, untargeted metabolomic analysis revealed marked disruption of NAD+ metabolism, accompanie...

Yan-Ni Wu, Xiao-Han Yang, Xian-Yang Jin et al. · 0 citations

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