Author

Ya-Guang Zhang

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Open access Oct 2026

Curcumin analogue FLLL32 induces ferroptosis by targeting the STAT3-GPX4/SLC40A1 axis in colorectal cancer

FLLL32 is a curcumin analogue with reported anti-tumor activity, mainly through inhibition of signal transducer and activator of transcription 3 (STAT3) signaling and induction of apoptosis. However, whether FLLL32 regulates ferroptosis in colorectal cancer (CRC) and the underlying mechanism remain unclear. Here, using...

Tong Wu, Meng-Qiu Hao, Qiu-Ye Luo et al. · Molecular Biomedicine · 0 citations

Open access Jul 2026

Targeting HASPIN-mediated H3T3 phosphorylation disrupts an epigenetic-kinesin axis to suppress colorectal cancer mitotic progression.

The findings identify the HASPIN/H3T3ph-KDM5B-H3K4me3-KIF axis as a targetable antimitotic pathway and support therapeutic inhibition of HASPIN/H3T3ph as a potential strategy for CRC.

Tong Wu, Yaguang Zhang, Si-Cheng Liu et al. · Molecular Cancer · 0 citations

Review Open access Jul 2026

tRNA-derived small RNAs in tumor microenvironment remodeling: From mechanistic insights to therapeutic perspectives

This review systematically summarizes the biogenesis and molecular mechanisms of tsRNAs and discusses how they regulate key TME-associated processes, including immune cell function, metabolic reprogramming, angiogenesis, and extracellular vesicle-mediated cell-cell communication, thereby contributing to tumor progressi...

Ya-Guang Zhang · Oncogene · 0 citations