Ya-Hong Wu

POTN-2: A deep learning-based predictor of HLA-A*02:01-restricted tumor neoantigens.

Tumor neoantigens arise from somatic mutations in malignant cells and are strictly tumor-specific, minimizing autoimmune risks, making them ideal targets for T-cell immunotherapy. However, conventional pan-HLA predictors suffer from reduced accuracy and high false-positive rates for individual HLA subtypes. Our prior P...