Ya-Jie Huang

Integrative bioinformatics screening of a M2 macrophage-associated gene signature for osimertinib resistance

Introduction Although the third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) Osimertinib is widely used in lung adenocarcinoma (LUAD), acquired resistance to this agent remains a major clinical challenge perplexing the academic community. While the genomic drivers of osimertinib resi...