Ya-Li Deng

SMURF1 alleviates preeclampsia by suppressing ferroptosis in trophoblast cells via mediating ubiquitination of FLT1.

BACKGROUND Ferroptosis, an emerging form of regulated cell death, and ubiquitination have not been fully clarified in preeclampsia (PE). Aberrant overexpression of Fms-like tyrosine kinase 1 (FLT1) is closely associated with PE development, yet the association between FLT1 and ferroptosis in PE, as well as the involvem...