Author

Ya-Nan Li

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Oct 2026

Intaermedin attenuates chronic intermittent hypoxia-induced renal fibrosis via SIRT1-mediated inhibition of the NOX4/ROS axis.

Obstructive sleep apnea hypopnea syndrome (OSAHS) is characterized by chronic intermittent hypoxia (CIH) and is an independent risk factor for chronic kidney disease (CKD); the underlying mechanism may involve oxidative stress. This study investigated the role of intermedin (IMD), a small antioxidant peptide, in CIH-in...

Yuan Ge, Yi-Lin Ren, Jun-Nan Guo et al. · Biochemical Pharmacology · 0 citations

Open access Sep 2026

Intermedin mitigates chronic intermittent hypoxia-induced metabolic reprogramming in tubular epithelial cells and attenuates consequent kidney fibrosis through an AMPK-dependent suppression of HIF-1α.

Obstructive sleep apnea-hypopnea syndrome (OSAHS) is an independent driver of chronic kidney disease (CKD). Its hallmark-chronic intermittent hypoxia (CIH)-induces oxidative stress, ultimately leading to kidney fibrosis. AMP-activated protein kinase (AMPK)-dependent suppression of hypoxia-inducible factor-1α (HIF-1α) r...

Yuan Ge, Juan Pan, Ya-Nan Li et al. · Free Radical Biology & Medic... · 0 citations

Case report Open access 2026

The clinical recognition, diagnosis and treatment of osteogenesis imperfecta: a case report and literature review.

The typical clinical symptoms, skeletal imaging features, and genetic test results of this patient ultimately confirmed the diagnosis of osteogenesis imperfecta and a multidisciplinary comprehensive individualized treatment plan was formulated and implemented for the patient, effectively alleviating clinical symptoms a...

Yifei Ma, Ya-Nan Li, Ruolin Lv et al. · International Journal of Cli... · 0 citations