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Author

Ya-Nan Wang

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Open access Sep 2026

Activation of TREM2 via single-domain antibodies improves synaptic and cognitive function in 5×FAD mice.

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, and dysfunction of triggering receptor expressed on myeloid cells 2 (TREM2) in microglia increases AD risk. TREM2 activation promotes protective microglial functions and mitigates AD pathology. Although TREM2-activating antibodies show therapeut...

Xiao-Xiao Yu, Qiao-Yun Ren, Yan-Chun Gao et al. · 0 citations

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