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Ya-Ning Wang

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Open access Sep 2026

Overcoming EGFR Resistance by Monovalent and Bident Inhibitors Targeting Cys775

Covalent targeting of EGFR cysteine 797 by osimertinib is one of the most successful breakthroughs in targeted therapy, fundamentally transforming the treatment landscape for non-small-cell lung cancer (NSCLC) patients. However, resistance driven by the mutation of C797 remains a major clinical challenge. Developing...

Zheng-Nian Li, Jie Jiang, Ya-Ning Wang et al. · 0 citations

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