Review
Open access
Sep 2026
Heterogeneity in cancer: molecular mechanisms and therapeutic strategies
The Holistic Integrative Tumor Ecosystem Theory (HITET) is proposed, a five-dimensional framework connecting these scales through functional interfaces that synthesizes how genetic alterations, cellular plasticity, metabolic programs, immune and stromal interactions, spatial gradients, organ-specific environments, micr...
Yong-Lin He, Liang Niu, Yan-Ming Ren et al.
· Signal Transduction and Targ... · 0 citations