Ya-Yun Zhang

AMPKα1 activation enhances mitophagy to counteract hypoxia-induced neuronal apoptosis in cervical spondylotic myelopathy and facilitates functional recovery mediated by rosmarinic acid.

BACKGROUND Cervical spondylotic myelopathy (CSM) involves progressive neurological dysfunction often linked to mitochondrial impairment. Mitophagy, a selective autophagic process, is crucial for neuronal homeostasis; however, its role in CSM and the specific involvement of AMPK subunits in TFEB-mediated mitophagy remai...