DNA Origami-Based Multivalent Nanobody Display Platform for Potent Neutralization of Botulinum Neurotoxin Type A.
By orderly assembling nanobodies on DNA origami, this study creates a biomimetic nanoscale trap with triple functions-"capture, enrichment, and sequestration"-against BoNT/A, which provides a highly efficient neutralization paradigm for anti-BoNT/A therapy and highlights the transformative potential of DNA origami nano...