Author

Yacine Kherdjemil

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Open access Sep 2026

Molecular analysis of Aldh1a2 conditional inactivation in developing limbs reveals mechanisms of retinoic-acid mediated interdigital apoptosis

Introduction Retinoic acid (RA) plays a plethora of functions during embryonic development as well as post-natal life. In particular, RA function during limb development is associated with interdigital cell death. However, the molecular mechanism(s) through which RA signaling contributes to interdigital cell death rema...

Rodrigue Peraldi, Yacine Kherdjemil, Gabriel Villiard et al. · Frontiers in Cell and Develo... · 0 citations

Open access Sep 2026

Chromatin context shapes SPT5 regulation of promoter-proximal Pol II, fine-tuning gene expression changes during Drosophila embryogenesis.

Transcription involves initiation, pausing, elongation, and termination. Suppressor of Ty5 (SPT5) regulates promoter-proximal pausing and elongation, but how it orchestrates both steps during dynamic developmental changes in gene expression remains unclear. Here, using rapid optogenetic depletion in Drosophila embryos,...

Alessandro Dulja, M. Mayer, Niklas L. Engel et al. · Developmental Cell · 0 citations