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Open access Oct 2026

Genome-wide CRISPR screening identified hemojuvelin as a non-neuronal receptor for the botulinum neurotoxin serotypes A and C.

Botulinum neurotoxins (BoNTs) enter cells primarily through neuronal receptors and gangliosides. However, the mechanism that enables their specific accumulation at neuromuscular junctions (NMJs) remains poorly understood. In this study, a genome-wide CRISPR-Cas9 screen identifies hemojuvelin (HJV), a membrane protein a...

Wan-Tong Ma, Bo Liu, Jing-Jing Gao et al. · 0 citations
Review Open access Aug 2026

Lactylation at the crossroads: Bridging metabolic rewiring and ferroptotic vulnerability in cancer

It is proposed that histone and non-histone lactylation serves as the critical “epigenetic bridge” coupling metabolic flux to ferroptosis evasion, offering a rational strategy to re-sensitize refractory tumors to ferroptosis-inducing therapies.

Ya-Li Liu, Qiang Yang, Xiaoqiang Wang et al. · 1 citation

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