Lactylation of USP11 fosters breast cancer development by stabilizing CDK4 and activating CDK4-RB1-E2F1 pathway
Cyclin-dependent kinase 4 (CDK4) is a key player in the cell cycle. Its frequent overexpression in a multitude of cancers correlates with increased cell proliferation and resistance to CDK4 inhibitors, highlighting the critical need to target CDK4 degradation as a therapeutic approach. However, the mechanisms governi...