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Aug 2026

Discovery of BMS-986449: A Potent, Selective Degrader of the Transcription Factors IKZF2 (Helios) and IKZF4 (Eos) to Target Regulatory T Cells in Solid Tumors.

BMS-986449 is an orally available degrader that demonstrates single-agent growth inhibition of syngeneic MC38 tumors implanted in humanized Cereblon (CRBN) knock-in mice and establishes BMS-986449 as a promising clinical candidate for cancer immunotherapy.

E. Cherney, S. Nair, Suresh Babu Viswa Krishna Penmetsa et al. · 1 citation
Aug 2026

Component-specific interaction between egg ovalbumin and edible oil fume particles in Chinese cooking: conformational remodeling drives changes in digestibility and allergenicity.

Interactions between food processing-derived components and food proteins can markedly alter protein conformation and functional properties. Among them, cooking oil fume particles (COFPs) are widespread contaminants from high-temperature Chinese cooking. This study first compared the effects of COFPs from four common e...

Wei Hu, Ziwen Hao, Shuang-Yan Zheng et al. · 0 citations

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