Author

Yan-Chun Peng

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Open access Aug 2026

Archipelago architecture and evolution of paclitaxel biosynthesis revealed by the Pseudotaxus chienii haplotype-resolved genome

The authors report genome assembly of Pseudotaxus chienii and show that, while it retains a largely conserved genomic architecture for paclitaxel biosynthesis, extensive degradation of the terminal pathway suggests a substantial loss of paclitaxel-producing capacity.

Huan Wang, Hai-Dong Chen, Ya-Ping Sun et al. · Nature Communications · 0 citations

Open access Jul 2026

Isoalantolactone inhibits pancreatic ductal adenocarcinoma progression via direct targeting of NLRP3-mediated inflammation-angiogenesis axis

IATL functions as a novel NLRP3 pathway inhibitor, suppressing angiogenesis through anti-inflammatory mechanisms, thereby effectively inhibiting PDAC progression and suggesting that IATL holds potential as a therapeutic agent for pancreatic cancer.

Ying Zhang, Changquan Liu, Shengjiang Liu et al. · Frontiers in Pharmacology · 0 citations