Author

Yan-Chun Peng

2 papers indexed here

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Open access Aug 2026

Mode of T cell priming durably shapes the TCR repertoire, effector function and α4β1 integrin expression of human virus-specific CD4+ T cells

The generation of an effective T cell response against an antigen depends on the recognition of the antigen by the T cell receptor (TCR), followed by T cell priming, initiating coordinated biophysical, biochemical and proliferative changes that drive differentiation into effector and memory clones. The immunological en...

E. Antoun, Gui-Hai Liu, D. Jayathilaka et al. · bioRxiv · 0 citations

Open access Sep 2026

Unveiling structural determinants of peptide recognition by public and private SARS-CoV-2-specific T-cell receptors

Public T cell receptors (TCRs) recurrently emerge across individuals in response to common pathogens, yet the structural and biophysical basis distinguishing public from private clonotypes remains incompletely defined. Here, we combine epitope mapping, single-cell TCR sequencing, and single-particle cryo-electron m...

Caner Akıl, Yan-Chun Peng, Julia McCarthy et al. · Nature Communications · 0 citations